Research Validates Folk Medicine for Pain Relief
A breakthrough study has scientifically validated what traditional healers have known about the sugar apple tree (Annona squamosa) for centuries. This widely cultivated tropical tree called “fruta-do-conde” in Brazil and “Seetha pazham” in India, produces leaves containing a powerful compound called palmatine that effectively relieves joint pain and inflammation.
Scientists examined both the whole leaf extract and isolated palmatine from A. squamosa, finding that both significantly reduced inflammation and pain in multiple experimental models. The compound proved especially effective at doses comparable to traditional medicinal preparations, supporting generations of folk medicine practice across tropical regions where the tree grows naturally.
The research revealed that palmatine targets TNF, a key molecule in inflammation and pain signaling. This discovery helps explain why traditional healers across Brazil, India, and the Philippines have successfully used sugar apple leaf preparations to treat joint problems and body pain.
Notably, the study found no toxic effects at therapeutic doses, though researchers note that future studies should explore optimal dosing and long-term safety. These findings open new possibilities for developing natural pain treatments based on this well-known tropical fruit tree.
Reference
Ito CNA, Sousa GF, Oliveira AR, et al. Analgesic and anti-arthritic potential of methanolic extract and palmatine obtained from Annona squamosa leaves. Pharmaceuticals. Published online January 2024. doi:10.3390/ph17010000
