One of the most important aspects of our health is our diet; what we put into our bodies as fuel and nutrition. A recent study in the FASEB journal suggests that for some individuals, overeating can be enough of a trigger to cause signs and worsening of metabolic disease. Even one high-calorie meal was enough to trigger metabolic effects in some of the participants.
Nineteen male participants were divided into two groups. One group was comprised of 10 healthy individuals, and the other was comprised of nine individuals with metabolic syndrome with two or more risk factors for heart disease. These risk factors included markers such as unhealthy cholesterol levels, high blood pressure, high blood sugar, high blood lipids, and increased abdominal fat. Both groups had blood work completed before and after a high calorie, high fat milkshake. Sixty-one biomarkers were then evaluated in the blood. It was discovered that biomedical processes related to sugar and fat metabolism, and inflammation were abnormal in those participants with metabolic syndrome. Healthy participants also received a high-sugar snack to consume, containing an extra 1300 kcal per day. These snacks were sweets such as candy bars, tarts, peanuts, and chips, and were consumed daily for four weeks. The same 61 biomarkers were examined and subtle negative changes were found consistent with that of metabolic syndrome. These findings further stress the importance of healthy eating as a daily habit.