An NPR segment last week showcased the use of naltrexonefor the treatment of alcoholism. Roughly 28% of American adults report drinking more than recommended, or are considered heavy drinkers, according to a recent NIH survey.1 This is a concern and a condition that has far-reaching repercussions into the community and healthcare system. Alcoholism is a condition, which many are embarrassed to seek treatment for because of the social stigma that often accompanies the admittance of problem drinking. Many people, including physicians, are not aware that there are prescriptions available that can significantly increase the likelihood of abstinence or diminished drinking habits.

The Sinclair Method

The Sinclair method,2 utilizes naltrexone, a known opioid antagonist, to diminish the neuro-emotional reinforcement of alcohol by interfering with endogenous opioid receptors in the brain. This is the same mechanism by which naltrexoneis used to combat opiate addiction. Since alcohol also stimulates endorphin receptors, taking naltrexonebefore drinking lessens the effects of alcohol, and also the reinforced conditioning which supports continued drinking behavior. This is a “self-administered” protocol, where patients need commit to taking the medication an hour or 2 before initiating alcohol use. It is not necessary for them to abstain, but rather drink as usual, with the added medication before drinking. But it has been shown that 78% of individuals who adhere to the protocol have significantly diminished alcohol use or abstinence.2,3 The Sinclair method uses a dose of 50mg naltrexone, however other individuals have seen success with smaller doses.

Naltrexone and Naturopathy Prove Positive, So Far

Sandra Olic, a naturopathic physician in Scottsdale, Arizona utilizes this method with good results. She uses 25 mg instead of 50, having her patients simply cut the tablets in half.  She affirms, “the key is to have them take it about an hour or 2 before they would have a drink.” She also maintains that treating alcoholic patients “naturopathically,” “their gut health, nutrient status and hormones obviously provide a more successful outcome than naltrexonealone.” Incorporating support groups, or counseling, also is advocated as improving the effectiveness of this treatment, however, these methods alone have historically been shown to have poor results.


  1. National Insitute on Alcohol Abuse and Alcoholism. Helping patients who drink too much: A clinician’s guide. NIH Publication no. 05-3769, Bethesda, MD 2005.
  2. Sinclair J, Chick J, Sørensen P, et al. Can alcohol dependent patients adhere to an ‘as-needed’ medication regimen? Eur Addict Res.2014;20(5):209-17. doi: 10.1159/000357865.
  3. Maisel NC, Blodgett JC, Wilbourne PL, et al. Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful? Addiction. 2013;108(2):275-93. doi: 10.1111/j.1360-0443.2012.04054.x.

Node Smith, associate editor for NDNR, is a fifth year naturopathic medical student at NUNM, where he has been instrumental in maintaining a firm connection to the philosophy and heritage of naturopathic medicine amongst the next generation of docs. He helped found the first multi-generational experiential retreat, which brings elders, alumni, and students together for a weekend campout where naturopathic medicine and medical philosophy are experienced in nature. Three years ago he helped found the non-profit, Association for Naturopathic ReVitalization (ANR), for which he serves as the board chairman. ANR has a mission to inspire health practitioners to embody the naturopathic principles through experiential education. Node also has a firm belief that the next era of naturopathic medicine will see a resurgence of in-patient facilities which use fasting, earthing, hydrotherapy and homeopathy to bring people back from chronic diseases of modern living; he is involved in numerous conversations and projects to bring about this vision. 

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